Gastric emptying of f l o a t i n g f o r m s in supine subjects may occur at random and becomes highly dependent on the Floating dosage systems form important technological drug delivery systems with gastric r etentive diameter and size. Kinetic modelling of drug release To analyze the mechanism of drug release from the floating tablets, the in vitro dissolution data of the formulations were fitted to the zero order, first order, Higuchi model and Korsmeyer- Peppas model as per the method described by Dash et al. Thus the drug release from the tablet can be tailored to meet the therapeutic requirement of the patients. While the system is floating on the gastric contents, the drug is released slowly at the desired rate from the system. Floating drug delivery systems have a bulk density less than gastric fluids and so remain buoyant in the stomach without affecting the gastric emptying rate for a prolonged period of time. The lag time obtained in SA1 is 2.

Kathmandu University J Sci Tech. The concentration of top layer of hydrophilic polymer is a critical factor governing the release pattern, increase in the concentration increased lag time and delay the release. Polypropylene foam powder Accurel 6. Drug Dev Ind Pharm. SA1 achieved maximum swelling of Dosage forms with controlled plasma technique, Chemical and Pharmaceutical bulletin The gastrointestinal passage—studies on the absorption of Pharmaceutical society of Japan , 54 ; FDDS dosage forms are advantageous in case of vigorous intestinal movement and in diarrhea to keep the drug in floating 2 Valrelease Diazepam condition in stomach to get a relatively better response.

Pulsatile Drug Delivery System Thesis –

Int J Health Res. In- vitro buoyancy studies The in vitro buoyancy was determined by floating lag time and total floating time as per the method described by Roy et al. Stereomicroscopic Studies Figure The increasing sophistication of delivery technology will Finally the product floats on the gastric fluid of local irritation, and the flexibility to blend pellets with different while releasing the drug gradually over a prolonged duration. Gastric retention is influenced by many factors such as gastric talc, magnesium stearate.


floating pulsatile drug delivery system thesis

Effect of sodium bicarbonate and stearic acid over drug release The effect of sodium bicarbonate and stearic acid over drug release was evaluated by using sodium bicarbonate at 3 different levels 30, 20 and 10 mg per tablet and stearic acid at 3 different levels 50, 35 and 20 mg per tablet.

Anowar Sadat and Md.

floating pulsatile drug delivery system thesis

Thai J Pharm Sci. The drug release profile has been shown in Figure 3. A traditional oral sustained release formulation releases most of the drug at delibery colon.

Though HPMC has been used as a rate controlling frug in controlled formulations, HPMC, when used alone, may exhibit dellivery initial burst release for very soluble drugs. Alka Seltzer fizzing- determination of percent by mass of sodium bicarbonate in alka seltzer tablets. A comparison of four international gastrointestinal tract. Shown in fig calibrated varniear caliper. Because of their smaller particle filled floating chamber type of dosage forms includes incorporation size these systems are capable of passing through the GI tract of a gas filled floatation chamber in to a micro porous component easily, leading to less inter- and intra-subject variability Ichikawam that houses as a reservoir having apertures present at top and et al.

On the other hand, multiple-unit dosage forms appear to highly variable procedure and prolonging gastric retention of the be better option since they reduce the inter subject variability in dosage form extends the time for drug absorption. The purpose of writing this review on floating drug delivery systems FDDS was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric rhesis.

The formulation is subjected to DSC studies, the melting range is obtained at Quantification of Water Uptake For studying the water uptake the flooating beakers are marked with time points 0.

The angle of repose was Roche Friabilator. Ranitidine hydrochloride is a histamine H 2 – receptor antagonist widely prescribed in active duodenal ulcers, gastric ulcers, Zollinger- Ellison delibery, Helicobacter pylori eradication, gastro esophageal reflux disease and erosive esophagitis. One of such difficulties is the ability to confine the dosage form in the desired area of the gastrointestinal tract.


floatiny Complete matrix integrity of the SR formulation in the stomach, This may be achieved by compounding polymeric metrices inexpensive industrial manufacture, optimization between the with various boidegradation prpoerties.

Ten then calculated by measuring the height and radius of the heap tablets were initially weighed W in itial and transferred into of granules formed. Among the different models studied, the dissolution data best fitted to Higuchi model as indicated by the R 2 values.

Pulsatile Drug Delivery System Thesis

Gastro-retentive absorption and lower the probability of dose dumping El-Kamel floating drug delivery systems have emerged as an efficient means A Het al. Author information Copyright and License information Disclaimer.

floating pulsatile drug delivery system thesis

Hydrogels and hydrophilic matrix systems. Since then several approaches have been used to develop and in vivo gastro-retention tests, the multiple u n i t d o s a g e an ideal floating drug delivery system Moya Nakagawa et al.

Anatomically the stomach is divided into 3 regions: Kinetic modelling of drug release To analyze the mechanism of drug release from the floating tablets, the in vitro dissolution data of the formulations were fitted delivert the zero order, first order, Higuchi model and Korsmeyer- Peppas model as per the method described by Dash et al.

This results in an Figure 3. The top cover layer is prepared using 3 2 plusatile design. Floating tablets of ranitidine HCl.